This research work targets the design and optimization of a bio-inspired pedestrian bridge. The bridge is made of lattice material, whose stress analysis is conducted by means of the theory of asymptotic homogenization, coupled with an optimization process that tailors the material properties to meet the functional requirements of the bridge. The analysis requires decoupling the system into two levels, system and component; the former represents the whole superstructure, the latter the cross- section of the bridge. The optimum solution describing the material properties of the bridge mapped into a lattice geometry, which enables the fabrication of the structure using additive manufacturing.