The material distribution routing problem in the manufacturing system is a complex combinatorial optimization problem and its main task is to deliver materials to the working stations with low cost and high efficiency. A multi-objective model was presented for the material distribution routing problem in mixed manufacturing systems, and it was solved by a hybrid multi-objective evolutionary algorithm (HMOEA). The characteristics of the HMOEA are as follows: 1) A route pool is employed to preserve the best routes for the population initiation; 2) A specialized best-worst route crossover (BWRC) mode is designed to perform the crossover operators for selecting the best route from Chromosomes 1 to exchange with the worst one in Chromosomes 2, so that the better genes are inherited to the offspring; 3) A route swap mode is used to perform the mutation for improving the convergence speed and preserving the better gene; 4) Local heuristics search methods are applied in this algorithm. Computational study of a practical case shows that the proposed algorithm can decrease the total travel distance by 51.66%, enhance the average vehicle load rate by 37.85%, cut down 15 routes and reduce a deliver vehicle. The convergence speed of HMOEA is faster than that of famous NSGA-II.