The short-term environmental/economic hydrothermal scheduling (SEEHS) with the consideration of multiple objectives is a complicated non-linear constrained optimization problem with non-smooth and non-convex characteristics. In this paper, a multi-objective optimization model of SEEHS is proposed to consider the minimal of fuel cost and emission effects synthetically, and the transmission loss, the water transport delays between connected reservoirs as well as the valve-point effects of thermal plants are taken into consideration to formulate the problem precisely. Meanwhile, a hybrid multi-objective cultural algorithm (HMOCA) is presented to deal with SEEHS problem by optimizing both two objectives simultaneously. The proposed method integrated differential evolution (DE) algorithm into the framework of cultural algorithm model to implement the evolution of population space, and two knowledge structures in belief space are redefined according to the characteristics of DE and SEEHS problem to avoid premature convergence effectively. Moreover, in order to deal with the complicated constraints effectively, new heuristic constraint handling methods without any penalty factor settings are proposed in this paper. The feasibility and effectiveness of the proposed HMOCA method are demonstrated by two case studies of a hydrothermal power system. The simulation results reveal that, compared with other methods established recently, HMOCA can get better quality solutions by reducing fuel cost and emission effects simultaneously.