In this paper, a multi-objective particle swarm optimization (MOPSO) algorithm and a nondominated sorting genetic algorithm II (NSGA-II) are used to optimize the operating parameters of a 1.6 L, spark ignition (SI) gasoline engine. The aim of this optimization is to reduce engine emissions in terms of carbon monoxide (CO), hydrocarbons (HC), and nitrogen oxides (NO (x) ), which are the causes of diverse environmental problems such as air pollution and global warming. Stationary engine tests were performed for data generation, covering 60 operating conditions. Artificial neural networks (ANNs) were used to predict exhaust emissions, whose inputs were from six engine operating parameters, and the outputs were three resulting exhaust emissions. The outputs of ANNs were used to evaluate objective functions within the optimization algorithms: NSGA-II and MOPSO. Then a decision-making process was conducted, using a fuzzy method to select a Pareto solution with which the best emission reductions can be achieved. The NSGA-II algorithm achieved reductions of at least 9.84%, 82.44%, and 13.78% for CO, HC, and NO (x) , respectively. With a MOPSO algorithm the reached reductions were at least 13.68%, 83.80%, and 7.67% for CO, HC, and NO (x) , respectively.