This paper presents a methodology for reliability-based multiobjective optimization of large-scale engineering systems. This methodology is applied to the vehicle crashworthiness design optimization for side impact, considering both structural crashworthiness and occupant safety, with structural weight and front door velocity under side impact as objectives. Uncertainty quantification is performed using two first order reliability method-based techniques: approximate moment approach and reliability index approach. Genetic algorithm-based multiobjective optimization software GDOT, developed in-house, is used to come up with an optimal pareto front in all cases. The technique employed in this study treats multiple objective functions separately without combining them in any form. It shows that the vehicle weight can be reduced significantly from the baseline design and at the same time reduce the door velocity. The obtained pareto front brings out useful inferences about optimal design regions. A decision-making criterion is subsequently invoked to select the "best" subset of solutions from the obtained nondominated pareto optimal solutions. The reliability, thus computed, is also checked with Monte Carlo simulations. The optimal solution indicated by knee point on the optimal pareto front is verified with LS-DYNA simulation results.