An improved cellular automata model of enzyme kinetics based on genetic algorithm

Abstract

Based on a generalized Cellular Automata (CA) model which has the flexibility of reaction 
interactions between all possible two-agent combinations on both reactant and product side, 
in previous studies by the authors, probabilistic reaction events were combined in a multiplicative 
order and an exploratory study of the variability analysis was performed. However it was found 
that the probabilistic parameter values are extremely sensitive to the final model output. As 
such, NSGA-II based on a Multi-objective Genetic Algorithm (MOGA) is used in this study to obtain 
optimum sets of these probability parameter values within a feasible computational time. For each 
generation of the MOGA, the probability rules parameter values are updated (improved) based on 
the objective functions. Finally, a validation study is performed to indicate the applicability 
of the CA model to represent specific enzymatic reactions when coupled with the multi-objective 
optimization algorithm.